The Magnesium Stearate Handbook

by Patrick C. Okoye



Book Details

Language : English
Publication Date : 11/18/2016

Format : Softcover
Dimensions : 6x9
Page Count : 110
ISBN : 9781532011115
Format : Hardcover
Dimensions : 6x9
Page Count : 110
ISBN : 9781532011139
Format : E-Book
Dimensions : N/A
Page Count : 110
ISBN : 9781532011122

About the Book

Magnesium stearate (MgSt) is widely used in cosmetic, food, and pharmaceutical formulations as lubricant in capsule and tablet manufacture at concentrations between 0.25% and 5%. A recent review of the top two hundred prescription drugs showed over 50% contained magnesium stearate. This book covered a broad spectrum of concentration from 1% to 10% for the purpose of presenting their unique properties during powder rheology, tableting, and effect on drug dissolution. MgSt also has both scientifi c and economic signifi cance, given its wide application in global pharmaceutical manufacturing. An understanding of polymorphism (or pseudopolymorphism) in magnesium stearate and the impact on tablet lubrication process and drug dissolution would provide a valuable tool to pharmaceutical scientists during excipient selection process for new product development and even during reformulation of existing products. Preformulation scientists spend a great deal of time reviewing excipients for new product development both in silico and on the bench. As a result, accurate selection of excipients, such as lubricants, could avoid potential issues with clinical batches, product scale-up, and product transfer during commercialization.

About the Author

Dr. Patrick C. Okoye is the founder and CEO of Griffin-Gamma LLC., a consulting firm that specializes in product development, quality systems development and recovery, product certifications, and renewable energy.

As a research pharmacist, Dr. Okoye has spent over two decades studying powder lubrication and magnesium stearate. Dr. Okoye worked at various levels in the pharmaceutical industry including manufacturing, technical services, drug formulation, regulatory compliance, and quality systems. He also served as senior executive in skincare and cosmetic manufacturing and packaging.

Dr. Okoye is an adjunct faculty member at Nebraska Institute of Forensic Sciences. He also serves on the advisory board of Afrimerica Global Missions, a nonprofit philanthropic organization.

Dr. Okoye earned his bachelor of pharmaceutical sciences from Nigeria, followed by a master’s of science in industrial pharmacy and cosmetic science from Long Island University, New York. He received his doctorate in pharmaceutics from Long Island University, New York. Dr. Okoye is also a certified pharmaceutical regulatory specialist.

Dr. Okoye has many peer-reviewed publications in numerous scientific journals including book chapters in pharmacokinetics and postmortem drug redistribution.